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Also, the indole core is substituted at R3 with a carbonyl group which happens to be also bonded to some napthalene moeity. Napthalene is usually a bicyclic composition of two fused benzene rings. This carbonyl bridge of JWH-018 classifies it like a ketone. JWH-018 can be an analog of THJ-018, during which the core indazole structure is substituted